Sodium Chloride → 8-Pyrrolidinyl-5,6,7,8-tetrahydroquinoline

HRID 704854Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 704854
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl[CH:7]1[C:16]2[N:15]=[CH:14][CH:13]=[CH:12][C:11]=2[CH2:10][CH2:9][CH2:8]1.[Cl-].[Na+]>O>[N:1]1([CH:7]2[C:16]3[N:15]=[CH:14][CH:13]=[CH:12][C:11]=3[CH2:10][CH2:9][CH2:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

5

Edukt 3

HCID 5234Sodium ChlorideHCID 31268PyrrolidineHCID 137121808-Chloro-5,6,7,8-tetrahydroquinoline

Produkt 1

HCID 139833798-Pyrrolidinyl-5,6,7,8-tetrahydroquinoline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Over a period of 7 minutes with stirring and while allowing it to heat up, 50 ml of pyrrolidine were added to a solution of 20 g of 8-chloro-5,6,7,8-tetrahydroquinoline in 50 ml of water. The temperature reached 57° C. at the end of the introduction and stirring was continued for 1 hour at this temperature. The temperature was then allowed to return to 20° C. and the reaction medium was saturated with sodium chloride and then was extracted with ether. The combined organic phases were dried and the solvents were eliminated under reduced pressure to obtain 20.22 g or 8-pyrrolidinyl-5,6,7,8-tetrahydroquinoline in the form of an oil.

Aufarbeitung

  1. temperatureto heat up
  2. customreached 57° C. at the end of the introduction
  3. stirringstirring
  4. waitwas continued for 1 hour at this temperature
  5. customto return to 20° C.
  6. extractionwas extracted with ether
  7. customThe combined organic phases were dried

Quellen und Nachweise

ORD-Eintrag
ord-fc1665e16535462bb4840f3eb7ec95b1
Quelldatensatz
uspto-grants-1991_01
Patentnummer
US04988810

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