Propionic anhydride → 2-Ethyl-4H-pyrido[2,3-d][1,3]oxazin-4-one
Reaktionsgleichung
[NH2:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[C:11](OC(=O)CC)(=O)[CH2:12][CH3:13]>>[CH2:12]([C:13]1[O:5][C:4](=[O:6])[C:3]2[CH:7]=[CH:8][CH:9]=[N:10][C:2]=2[N:1]=1)[CH3:11]Komponenten
3
Reaktionsbedingungen
- Temperatur
- 120 °C
Versuchsvorschrift
A suspension of 2-aminonicotinic acid (1.0 g 7.24 mmol) in propionic anhydride (10 mL) of was heated to 120° C. for 1 h under nitrogen atmosphere. The temperature was increased to 167° C. to remove the propionic acid and propionic anhydride under reduced pressure. The resulting brown solid was triturated with hexane and dried to give the title pyrido-oxazine (16) (1.10 g, 86%) as a white solid:
Aufarbeitung
- temperatureThe temperature was increased to 167° C.
- customto remove the propionic acid and propionic anhydride under reduced pressure
- customThe resulting brown solid was triturated with hexane
- customdried
Quellen und Nachweise
- ORD-Eintrag
- ord-a8760626e5ce49a4819cd5d53a096c70
- Quelldatensatz
- uspto-grants-2015_11
- Patentnummer
- US09173869B2
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