Water → HCID 58452602, Verbindung

HRID 70566

Reaktionsgleichung

Reaktionsgleichung von HRID 70566
[OH-].[K+].Br[CH2:4][CH:5]([CH3:7])[CH3:6].[Br:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][OH:17])=[CH:11][CH:10]=1.O>CS(C)=O>[Br:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][O:17][CH2:4][CH:5]([CH3:7])[CH3:6])=[CH:11][CH:10]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 65551-Bromo-2-methylpropaneHCID 14797Potassium HydroxideHCID 728512-(4-Bromophenyl)ethanol

Produkt 1

HCID 58452602HCID 58452602, VerbindungAusbeute 70 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Versuchsvorschrift

Potassium hydroxide (1.32 g) and 1-bromo-2-methylpropane (1.04 mL) were added to a solution of 2-(4-bromophenyl)ethylalcohol (140 μL) in dimethyl sulfoxide (2 mL), and the mixture was stirred at room temperature overnight. Water was added to the reaction solution, followed by extraction with dichloromethane. The organic layer was filtered through diatomaceous earth and the filtrate was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane only) to give the title compound as a colorless oil (180 mg, 70%).

Aufarbeitung

  1. extractionfollowed by extraction with dichloromethane
  2. filtrationThe organic layer was filtered through diatomaceous earth
  3. customthe filtrate was evaporated under reduced pressure
  4. customThe residue was purified by silica gel column chromatography (hexane only)

Quellen und Nachweise

ORD-Eintrag
ord-e7e49ce9aa2a40a69c28271e7938841f
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08822503B2

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