Dimethylamine → (5-Methoxy-benzooxazol-2-yl)-dimethyl-amine

HRID 706231Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 706231
Cl[C:2]1[O:3][C:4]2[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:5]=2[N:6]=1.[CH3:13][NH:14][CH3:15]>O>[CH3:12][O:11][C:8]1[CH:9]=[CH:10][C:4]2[O:3][C:2]([N:14]([CH3:15])[CH3:13])=[N:6][C:5]=2[CH:7]=1

Komponenten

4

Edukt 2

HCID 674DimethylamineHCID 118197122-Chloro-5-methoxy-1,3-benzoxazole

Produkt 1

HCID 57344577(5-Methoxy-benzooxazol-2-yl)-dimethyl-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 2-chloro-5-methoxy-benzooxazole (1.52 g, 8.31 mmol) and a 40% solution of dimethylamine in water (15 mL) was refluxed for two hours before it was cooled to room temperature and partitioned between ethyl acetate and water. The organic layer was dried over anhydrous sodium sulfate and concentrated in vacuo to give the title compound as a black oil (1.14 g): MS: (+) m/z 397.19 (M+1)

Aufarbeitung

  1. custompartitioned between ethyl acetate and water
  2. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  3. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-fc7d307fa3154de2a505344361e69955
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09174976B2

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