5-Aminobenzimidazole → HCID 178446913, Verbindung

HRID 706272

Reaktionsgleichung

Reaktionsgleichung von HRID 706272
FC(F)(F)C([O-])=O.[NH2:8][C:9]1[CH:17]=[CH:16][C:12]2[N:13]=[CH:14][NH:15][C:11]=2[CH:10]=1.[CH2:18]([O:23][C:24]1[CH:31]=[CH:30][C:27]([CH:28]=O)=[CH:26][CH:25]=1)[CH2:19][CH2:20][CH2:21][CH3:22].[Si](C#N)(C)(C)C.[N:38]1([C:43](N2C=CN=C2)=[O:44])C=CN=[CH:39]1>>[NH:13]1[C:12]2[CH:16]=[CH:17][C:9]([N:8]3[CH:28]([C:27]4[CH:30]=[CH:31][C:24]([O:23][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH:25][CH:26]=4)[CH2:39][NH:38][C:43]3=[O:44])=[CH:10][C:11]=2[N:15]=[CH:14]1

Komponenten

6

Edukt 5

HCID 136235-AminobenzimidazoleHCID 682631,1'-CarbonyldiimidazoleHCID 79815p-PentoxybenzaldehydeHCID 82115Trimethylsilyl cyanideHCID 84468Trifluoroacetate

Produkt 1

HCID 178446913HCID 178446913, Verbindung

Versuchsvorschrift

The compound was synthesized as trifluoroacetate salt starting from 5-aminobenzimidazole (0.585 g, 4.4 mmol), 4-pentoxybenzaldehyde (0.755 mL, 4 mmol), TMSCN (0.5 mL, 4 mmol), PdC (10%, 0.02 g), TEA (1.05 mL, 7.4 mmol), di-(imidazol-1-yl)methanone (0.667 g, 4.12 mmol) as described in method 2. The product was purified by means of preparative HPLC.

Aufarbeitung

  1. customThe product was purified by means of preparative HPLC

Quellen und Nachweise

ORD-Eintrag
ord-9dc70e34720b4a39bd933560a6186d95
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09173885B2

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