Ethyl 6-(prop-1-en-2-yl)picolinate → Ethyl 6-isopropylpicolinate

HRID 706723Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 706723
[CH2:1]=[C:2]([C:4]1[N:9]=[C:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:7]=[CH:6][CH:5]=1)[CH3:3]>CCO.[Pd]>[CH:2]([C:4]1[N:9]=[C:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:7]=[CH:6][CH:5]=1)([CH3:3])[CH3:1]

Komponenten

4

Edukt 1

HCID 67974687Ethyl 6-(prop-1-en-2-yl)picolinate

Produkt 1

HCID 67974663Ethyl 6-isopropylpicolinateAusbeute 93 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

To ethyl 6-(prop-1-en-2-yl)picolinate (4.63 g, 24.2 mmol) in EtOH (50 mL) was added Pd/C (0.61 g, 0.573 mmol). The reaction mixture was purged with nitrogen and hydrogen three times each. A hydrogen balloon was applied to the reaction for three hours. The reaction was then purged with nitrogen, filtered through Celite® and washed with EtOH (100 mL). Solvent was removed under reduced pressure to give the desired product (93%).

Aufarbeitung

  1. customThe reaction mixture was purged with nitrogen and hydrogen three times each
  2. customA hydrogen balloon was applied to the reaction for three hours
  3. customThe reaction was then purged with nitrogen
  4. filtrationfiltered through Celite®
  5. washwashed with EtOH (100 mL)
  6. customSolvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-a60ecab01f16470b85fe20fcb765939a
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09174981B2

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