Morpholine → 4-Morpholinobut-2-YN-1-OL

HRID 706886Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 706886
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl[CH2:8][C:9]#[C:10][CH2:11][OH:12]>C1(C)C=CC=CC=1>[O:4]1[CH2:5][CH2:6][N:1]([CH2:8][C:9]#[C:10][CH2:11][OH:12])[CH2:2][CH2:3]1

Komponenten

4

Edukt 2

HCID 8083MorpholineHCID 2027752-Butyn-1-ol, 4-chloro-

Produkt 1

HCID 31128494-Morpholinobut-2-YN-1-OL

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel2×

Reaktionsbedingungen

Temperatur
85 °C

Versuchsvorschrift

To a solution of morpholine (4.36 g) in toluene (15 mL) was added 4-chlorobut-2-yn-1-ol (2.09 g) in toluene (5 mL). The solution was stirred at 85° C. for 3 hours. After cooling, the solid was filtered off. The filtrate was subjected to vacuum distillation to give the pure title compound.

Aufarbeitung

  1. temperatureAfter cooling
  2. filtrationthe solid was filtered off
  3. distillationThe filtrate was subjected to vacuum distillation

Quellen und Nachweise

ORD-Eintrag
ord-a4e3f6ea8f03421d80b5432a65bb7814
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09174982B2

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