Water → HCID 67126688, Verbindung

HRID 707035Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 707035
[Cl:1][C:2]1[CH:3]=[C:4]([S:25]([NH2:28])(=[O:27])=[O:26])[CH:5]=[N:6][C:7]=1[O:8][CH2:9][C:10]1([F:24])[CH2:15][CH2:14][C:13]2(OC3C=CC=CC=3[O:16]2)[CH2:12][CH2:11]1.C1(C)C=CC(S([O-])(=O)=O)=CC=1.[NH+]1C=CC=CC=1.O>CC(C)=O.ClCCl>[Cl:1][C:2]1[CH:3]=[C:4]([S:25]([NH2:28])(=[O:27])=[O:26])[CH:5]=[N:6][C:7]=1[O:8][CH2:9][C:10]1([F:24])[CH2:15][CH2:14][C:13](=[O:16])[CH2:12][CH2:11]1

Komponenten

6

Edukt 3

HCID 962WaterHCID 466102Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1)HCID 671269175-Chloro-6-((4'-fluoro spiro[benzo[d][1,3]dioxole-2,1'-cyclohexane]-4'-yl)methoxy)pyridine-3-sulfonamide

Produkt 1

HCID 67126688HCID 67126688, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 180AcetoneLösungsmittelHCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

To a solution of EXAMPLE 350D (1.6 g) and pyridinium p-toluenesulfonate (1.2 g) in acetone (10 mL) was added water (2 mL) and the mixture was stirred under microwave irradiation at 100° C. for 10 minutes. The mixture was diluted with dichloromethane (300 mL) and washed with aqueous NaHCO3, water, brine and dried over Na2SO4. Filtration and evaporation of the solvent gave the title compound.

Aufarbeitung

  1. washwashed with aqueous NaHCO3, water, brine
  2. dry with materialdried over Na2SO4
  3. filtrationFiltration and evaporation of the solvent

Quellen und Nachweise

ORD-Eintrag
ord-1798208f38d84a72a695f9de503923ac
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09174982B2

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