Dimethylformamide → HCID 71268660, Verbindung

HRID 70785Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 70785
[CH2:1](Cl)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[Na+].[Na+].CN(C=O)C.Cl.[CH3:21][C:22]1([C:28]([NH2:30])=[O:29])[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1>CCOC(C)=O.O>[CH2:1]([N:25]1[CH2:26][CH2:27][C:22]([CH3:21])([C:28]([NH2:30])=[O:29])[CH2:23][CH2:24]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

7

Edukt 4

HCID 6228DimethylformamideHCID 7503Benzyl ChlorideHCID 10340Sodium CarbonateHCID 675063694-Methyl-piperidine-4-carboxylic acid aMide hydrochloride

Produkt 1

HCID 71268660HCID 71268660, VerbindungAusbeute 97,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

Benzyl chloride (1.90 g) and sodium carbonate (1.59 g) were added to a DMF (70 ml) suspension of 4-methylpiperidine-4-carboxamide hydrochloride (2.24 g), and stirring was performed at room temperature for 16 hours. After adding water to the reaction liquid, extraction was performed with EtOAc. The organic layer was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (MeOH/chloroform) to obtain 1-benzyl-4-methylpiperidine-4-carboxamide (2.85 g).

Aufarbeitung

  1. customto the reaction liquid, extraction
  2. concentrationThe organic layer was concentrated under reduced pressure
  3. customthe residue was purified by silica gel column chromatography (MeOH/chloroform)

Quellen und Nachweise

ORD-Eintrag
ord-7dc46dc1d2794a90b2f0c8c24f019f0b
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08822688B2

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