Acetic Anhydride → N-(4-methyl-5-nitropyridin-2-yl)acetamide

HRID 708604

Reaktionsgleichung

Reaktionsgleichung von HRID 708604
[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4]([NH2:11])[CH:3]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>>[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4]([NH:11][C:12](=[O:14])[CH3:13])[CH:3]=1

Komponenten

3

Edukt 2

HCID 7918Acetic AnhydrideHCID 2431652-Amino-4-methyl-5-nitropyridine

Produkt 1

HCID 13567013N-(4-methyl-5-nitropyridin-2-yl)acetamide

Versuchsvorschrift

4-Methyl-5-nitro-pyridin-2-ylamine (1.0 g) was treated with acetic anhydride according to General Procedure Y to give N-(4-Methyl-5-nitro-pyridin-2-yl)-acetamide (1.1 g). LCMS (m/z): 196. N-(4-Methyl-5-nitro-pyridin-2-yl)-acetamide (0.5 g) was reduced under hydrogen atmosphere according to General Procedure Z to give N-(5-Amino-4-methyl-pyridin-2-yl)-acetamide (0.4 g), LCMS (m/z): 166. This was converted to 6-acetylamino-4-methyl-pyridine-3-sulfonyl chloride (0.35 g) according to General Procedure AA. LCMS (m/z): 249.

Quellen und Nachweise

ORD-Eintrag
ord-ca97001ecff64d6db670bfd2d546a10a
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09175003B2

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