Methanesulfonyl chloride → N-[1-(2-Chlorophenyl)-2-nitroethyl]methanesulphonamide

HRID 709135Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 709135
[CH3:1][S:2](Cl)(=[O:4])=[O:3].Cl.[Cl:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH:14]([NH2:19])[CH2:15][N+:16]([O-:18])=[O:17]>N1C=CC=CC=1>[Cl:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH:14]([NH:19][S:2]([CH3:1])(=[O:4])=[O:3])[CH2:15][N+:16]([O-:18])=[O:17]

Komponenten

4

Edukt 2

HCID 31297Methanesulfonyl chlorideHCID 866947771-(2-Chlorophenyl)-2-nitroethanamine hydrochloride

Produkt 1

HCID 68032403N-[1-(2-Chlorophenyl)-2-nitroethyl]methanesulphonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

At RT, 182 μl (2.35 mmol) of methanesulphonyl chloride were added to a solution of 300 mg (about 93% pure, 1.18 mmol) of the compound of Example 25A in 7.2 ml of pyridine, and the mixture was stirred for 1 h. The pyridine was removed on a rotary evaporator and the residue was purified by preparative HPLC [Method 20]. This gave 221 mg (65% of theory) of the title compound.

Aufarbeitung

  1. customThe pyridine was removed on a rotary evaporator
  2. customthe residue was purified by preparative HPLC [Method 20]

Quellen und Nachweise

ORD-Eintrag
ord-b35e8a953cb447759a4d29e4b39738ad
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09180120B2

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