Methanesulfonyl chloride → HCID 56848687, Verbindung

Reaktionsgleichung

Cl.[NH2:2][CH:3]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[C:31]([F:34])([F:33])[F:32])[CH2:4][NH:5][C:6](=[O:24])[CH2:7][N:8]1[C:12](=[O:13])[N:11]([CH2:14][CH2:15][O:16][CH3:17])[C:10]([C:18]2[S:19][C:20]([Cl:23])=[CH:21][CH:22]=2)=[N:9]1.[CH3:35][S:36](Cl)(=[O:38])=[O:37]>>[Cl:23][C:20]1[S:19][C:18]([C:10]2[N:11]([CH2:14][CH2:15][O:16][CH3:17])[C:12](=[O:13])[N:8]([CH2:7][C:6]([NH:5][CH2:4][CH:3]([NH:2][S:36]([CH3:35])(=[O:38])=[O:37])[C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[C:31]([F:32])([F:33])[F:34])=[O:24])[N:9]=2)=[CH:22][CH:21]=1

Komponenten

Edukt 2

HCID 31297Methanesulfonyl chloride

HCID 89764091HCID 89764091, Verbindung

Produkt 1

HCID 56848687HCID 56848687, Verbindung

Versuchsvorschrift

Analogously to the procedure of Example 68, 29 mg (46 μmol) of the compound of Example 60A were reacted with methanesulphonyl chloride. This gave 25 mg (92% of theory) of the title compound.

Quellen und Nachweise

ORD-Eintrag: ord-d49192dd9046487bb72479e4bba8301b
Quelldatensatz: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US09180120B2

Notizen zur Reaktion

Wird geladen…