Hydrochloric Acid → 1-Amino-3-(3,4-dimethoxyphenoxy)propan-2-one hydrochloride

HRID 710062Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 710062
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:14]=[CH:15][C:16]=1[O:17][CH3:18])[O:6][CH2:7][C:8](=[O:13])[CH2:9][N+:10]([O-])=O.[ClH:19].[H][H]>[Pd].CO>[ClH:19].[NH2:10][CH2:9][C:8](=[O:13])[CH2:7][O:6][C:5]1[CH:14]=[CH:15][C:16]([O:17][CH3:18])=[C:3]([O:2][CH3:1])[CH:4]=1

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 867067741-(3,4-Dimethoxyphenoxy)-3-nitropropan-2-oneHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 867067751-Amino-3-(3,4-dimethoxyphenoxy)propan-2-one hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a MeOH (7 ml) solution of the compound (0.660 g) obtained in Example 19-(2), 10% Pd—C (0.330 g) and an aqueous solution of 1N HCl (14 ml) were added and the mixture was stirred at room temperature for 5 hours in a hydrogen gas atmosphere. The insoluble matter was filtered off and the filtrate was concentrated to give the titled compound (0.715 g, brown amorphous.)

Aufarbeitung

  1. filtrationThe insoluble matter was filtered off
  2. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-0343177e56eb4de2aea60c267dd6a7c7
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09181229B2

Notizen zur Reaktion

Wird geladen…