2-Benzyl-hexahydro-cyclopenta[c]pyrrole-3a-carboxylic acid methyl ester → HCID 66977181, Verbindung

HRID 712225

Reaktionsgleichung

Reaktionsgleichung von HRID 712225
C([N:8]1[CH2:12][C:11]2([C:16]([O:18][CH3:19])=[O:17])[CH2:13][CH2:14][CH2:15][CH:10]2[CH2:9]1)C1C=CC=CC=1>CO.[OH-].[Pd+2].[OH-]>[CH2:9]1[CH:10]2[CH2:15][CH2:14][CH2:13][C:11]2([C:16]([O:18][CH3:19])=[O:17])[CH2:12][NH:8]1

Komponenten

4

Edukt 1

HCID 41183282-Benzyl-hexahydro-cyclopenta[c]pyrrole-3a-carboxylic acid methyl ester

Produkt 1

HCID 66977181HCID 66977181, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9942167Palladium hydroxideKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a stirred solution of methyl 2-benzyloctahydrocyclopenta[c]pyrrole-3a-carboxylate (2.0 g, 7.69 mmol) in MeOH (15.0 mL) was added palladium hydroxide (0.20 g, 10% w/w) and the mixture stirred at rt for 16 h under H2 atmosphere. After completion of reaction (by TLC), the reaction mixture was passed through celite and the solvent evaporated. The crude (1.50 g) residue was carried forward for the next step without further purification. MS: 170.18 [M+H]+.

Aufarbeitung

  1. customAfter completion of reaction (by TLC)
  2. customthe solvent evaporated
  3. customThe crude (1.50 g) residue was carried forward for the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-09a6abba829b491280d5efffeeb37fb7
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09181234B2

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