HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sodium Carbonate → 3-(Trifluoromethyl)benzyl 4-hydroxy-1-(3-(trifluoromethyl)benzyl)pyrrolidine-2-carboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sodium Carbonate | HCID 10340 | — |
| Edukt | 1-(Bromomethyl)-3-(trifluoromethyl)benzene | HCID 123061 | — |
| Edukt | Cis-4-Hydroxy-D-Proline | HCID 440014 | — |
| Produkt | 3-(Trifluoromethyl)benzyl 4-hydroxy-1-(3-(trifluoromethyl)benzyl)pyrrolidine-2-carboxylate | HCID 90353857 | — |
Reaktionsschritte
The title compound (D81) (1.02 g) was prepared according to the general procedure for substituted benzyl amines preparation starting from cis-4-Hydroxy-D-proline (4.0 g; available from Aldrich#H5877) and 3-(Trifluoromethyl)benzyl bromide (9.37 ml). (Na2CO3: 2.5 eq; Reaction time: 24 hrs; 60° C.).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09181279B2 |
| Quelldatensatz | uspto-grants-2015_11 |
| ORD ID | ord-47c1ce7c4c6d4ae78b39c83b454689b6 |
| Quellennotiz | uspto-grants-2015_11 |