Diethyl Ether → 2-[(Cyclopropylmethyl-amino)-methyl]-3,5,7,8-tetrahydro-pyrano[4,3-d]pyrimidin-4-one

tert-butyl cyclopropylmethyl((4-oxo-4,5,7,8-tetrahydro-3H-pyrano[4,3-d]pyrimidin-2-yl)methyl)carbamate (5.639 g, 16.81 mmol) was dissolved in 4 N HCl in dioxane (40 mL) and stirred at room temperature after approximately 5 min a white suspension formed and the reaction was allowed to stir overnight. 100 mL diethyl ether was added and the reaction mixture was filtered, washed with diethyl ether (2×25 mL) and dried in vacuo to yield the title compound as a white solid (4.819 g).

1. customformed
2. stirringto stir overnight
3. filtrationthe reaction mixture was filtered
4. washwashed with diethyl ether (2×25 mL)
5. customdried in vacuo

ORD-Eintrag

ord-abd6badb1f7041fd95650acc9883a40e

Quelldatensatz

uspto-grants-2015_11

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09181266B2