Trimethylsilyldiazomethane → Methyl 3-acetylbenzoate

HRID 714457Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 714457
[C:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7]([OH:9])=[O:8])(=[O:3])[CH3:2].[CH3:13][Si](C=[N+]=[N-])(C)C>C1(C)C=CC=CC=1.CO.C(OCC)C>[C:1]([C:4]1[CH:5]=[C:6]([C:7]([O:9][CH3:13])=[O:8])[CH:10]=[CH:11][CH:12]=1)(=[O:3])[CH3:2]

Komponenten

6

Edukt 2

HCID 167693Trimethylsilyldiazomethane2×HCID 2203243-Acetylbenzoic acid

Produkt 1

HCID 15094405Methyl 3-acetylbenzoate

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 887MethanolLösungsmittelHCID 1140TolueneLösungsmittelHCID 3283Diethyl EtherLösungsmittel2×

Versuchsvorschrift

3.95 g (24.06 mmol) of 3-acetylbenzoic acid were initially charged in 100 ml of toluene and 75 ml of methanol. After dropwise addition of 4.12 g (36.09 mmol) of trimethylsilyldiazomethane 2M in diethyl ether at RT, an instant evolution of gas in the reaction solution was observed. Another 0.27 g (2.4 mmol) of trimethylsilyldiazomethane 2M in diethyl ether was added until the reaction solution remained yellow, and the mixture was stirred at RT for 10 min. The reaction solution was evaporated.

Aufarbeitung

  1. customThe reaction solution was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-a4185f0c5e674338ac906d2a2b68008f
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09187428B2

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