Water → HCID 68614914, Verbindung

HRID 714460

Reaktionsgleichung

Reaktionsgleichung von HRID 714460
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH2:17][CH2:18][O:19][CH3:20])=[CH:12][CH:11]=2)[C:5]([C:21]#[N:22])=[C:4]([SH:23])[N:3]=1.Br[CH:25]([C:27]1[CH:28]=[C:29]([C:33]([O:35][CH3:36])=[O:34])[CH:30]=[CH:31][CH:32]=1)[CH3:26].C(=O)(O)[O-].[Na+].O>CN(C=O)C>[NH2:1][C:2]1[N:3]=[C:4]([S:23][CH:25]([C:27]2[CH:28]=[C:29]([C:33]([O:35][CH3:36])=[O:34])[CH:30]=[CH:31][CH:32]=2)[CH3:26])[C:5]([C:21]#[N:22])=[C:6]([C:10]2[CH:11]=[CH:12][C:13]([O:16][CH2:17][CH2:18][O:19][CH3:20])=[CH:14][CH:15]=2)[C:7]=1[C:8]#[N:9]

Komponenten

6

Edukt 4

HCID 962WaterHCID 516892Sodium BicarbonateHCID 20428675HCID 20428675, VerbindungHCID 178496105HCID 178496105, Verbindung

Produkt 1

HCID 68614914HCID 68614914, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

300 mg (0.919 mmol) of 2-amino-4-[4-(2-methoxyethoxy)phenyl]-6-sulfanylpyridine-3,5-dicarbonitrile (Example 15A), 245 mg (1.01 mmol) of methyl 3-(1-bromoethyl)benzenecarboxylate (Example 61A) and 231 mg (2.76 mmol) of sodium bicarbonate were dissolved in 3 ml of DMF and the mixture was stirred at RT overnight. Water was added to the reaction mixture until a clear solution had formed. The solution was purified by preparative HPLC (Chromasil, water/acetonitrile+0.1% trifluoroacetic acid).

Aufarbeitung

  1. customhad formed
  2. customThe solution was purified by preparative HPLC (Chromasil, water/acetonitrile+0.1% trifluoroacetic acid)

Quellen und Nachweise

ORD-Eintrag
ord-db85723dec71408d9e68fd31250524fd
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09187428B2

Verknüpfte Notizen

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