Water → N-(5-Nitro-pyrimidin-2-yl)-benzamide

HRID 714576

Reaktionsgleichung

Reaktionsgleichung von HRID 714576
[NH2:1][C:2]1[N:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1.[C:11](Cl)(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.O>N1C=CC=CC=1>[C:11]([NH:1][C:2]1[N:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1)(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 7412Benzoyl chlorideHCID 764905-Nitropyrimidin-2-amine

Produkt 1

HCID 57699955N-(5-Nitro-pyrimidin-2-yl)-benzamideAusbeute 45,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

To stirred solution of 2-amino-5-nitropyrimidine (1.0 g, 7.14 mmol) in pyridine (20 ml) was added benzoyl chloride (0.92 ml, 7.93 mmol). The mixture was refluxed for 4 hr under nitrogen atmosphere. The reactant mixture was cooled to the room temperature and poured into 200 ml water. The resulting mixture was stirred overnight and then filtered in vacuo. The filter cake was washed with water (20 ml*3) and dried in vacuo to give 2-(N-benzoyl)amino-5-nitropyrimidine as a white solid (790 mg).

Aufarbeitung

  1. temperatureThe mixture was refluxed for 4 hr under nitrogen atmosphere
  2. filtrationfiltered in vacuo
  3. washThe filter cake was washed with water (20 ml*3)
  4. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-4703bc90db2a4c779ad15f3d7b8b4ead
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09187458B2

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