Methyl iodide → 2-(Methylthio)-1H-pyrimidin-4-one

HRID 714893

Reaktionsgleichung

Reaktionsgleichung von HRID 714893
[OH-].[Na+].[S:3]=[C:4]1[NH:9][C:8](=[O:10])[CH:7]=[CH:6][NH:5]1.I[CH3:12]>C(O)(=O)C>[CH3:12][S:3][C:4]1[NH:9][C:8](=[O:10])[CH:7]=[CH:6][N:5]=1

Komponenten

5

Edukt 3

HCID 6328Methyl iodideHCID 14798Sodium HydroxideHCID 1269845Thiouracil

Produkt 1

HCID 798232-(Methylthio)-1H-pyrimidin-4-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

To an aqueous solution (200 mL) of sodium hydroxide (23 g) were added 2-thioxo-2,3-dihydropyrimidin-4(1H)-one (37 g) and iodomethane (20 mL), and the mixture was stirred overnight at room temperature. To the reaction mixture was added acetic acid (17 mL), and the precipitate was collected by filtration, and washed with ice water. The residue was dried to give the title compound (28 g).

Aufarbeitung

  1. filtrationthe precipitate was collected by filtration
  2. washwashed with ice water
  3. customThe residue was dried

Quellen und Nachweise

ORD-Eintrag
ord-74fa7b4aec504bbdbd472f003f2699b9
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09187453B2

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