2,6-Difluorobenzoic acid → Sodium 2,6-difluorobenzoate

HRID 714930Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 714930
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([OH:6])=[O:5].[OH-].[Na+:13]>CCO.O>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([O-:6])=[O:5].[Na+:13]

Komponenten

5

Edukt 2

HCID 97962,6-Difluorobenzoic acidHCID 14798Sodium Hydroxide

Produkt 1

HCID 23698872Sodium 2,6-difluorobenzoateAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of 2,6-difluorobenzoic acid (1.00 g, 6.3 mmol) in EtOH and water (5:1, 60 mL) was added 1N aqueous sodium hydroxide solution (6.33 mL, 6.3 mmol). The reaction mixture was stirred for 10 minutes at room temperature and then solvents were removed in vacuo to yield sodium 2,6-difluorobenzoate (1.22 g, 6.3 mmol, quantitative) as an off white solid. 1H NMR (DMSO) δ 6.89 (2H, m), 7.15 (1H, m).

Aufarbeitung

  1. customsolvents were removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-42caf2d19a924c09b8ec9a72668f2496
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09187465B2

Notizen zur Reaktion

Wird geladen…