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Binap, (A+-)- → 1-(2-(6-(hydroxymethyl)pyridin-3-ylamino)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one

HRID 716047
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 716047
Br[C:2]1[N:3]=[C:4]2[C:10]([C:11](=[O:16])[C:12]([CH3:15])([CH3:14])[CH3:13])=[CH:9][N:8]([CH2:17][O:18][CH2:19][CH2:20][Si:21]([CH3:24])([CH3:23])[CH3:22])[C:5]2=[N:6][CH:7]=1.[NH2:25][C:26]1[CH:27]=[CH:28][C:29]([CH2:32][OH:33])=[N:30][CH:31]=1.CC([O-])(C)C.[Na+].C1C=CC(P(C2C(C3C(P(C4C=CC=CC=4)C4C=CC=CC=4)=CC=C4C=3C=CC=C4)=C3C(C=CC=C3)=CC=2)C2C=CC=CC=2)=CC=1>C1(C)C=CC=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[OH:33][CH2:32][C:29]1[N:30]=[CH:31][C:26]([NH:25][C:2]2[N:3]=[C:4]3[C:10]([C:11](=[O:16])[C:12]([CH3:15])([CH3:14])[CH3:13])=[CH:9][N:8]([CH2:17][O:18][CH2:19][CH2:20][Si:21]([CH3:24])([CH3:23])[CH3:22])[C:5]3=[N:6][CH:7]=2)=[CH:27][CH:28]=1
KomponentenReaktionsbedingungenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

7

Edukt 4

HCID 634876Binap, (A+-)-HCID 20583240(5-Aminopyridin-2-YL)methanolHCID 23676156Sodium t-butoxideHCID 578292211-(2-bromo-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-yl)-2,2-dimethylpropane-1-one

Produkt 1

HCID 71015368
1-(2-(6-(hydroxymethyl)pyridin-3-ylamino)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one
Ausbeute 36,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9811564Bis(dibenzylideneacetone)palladiumKatalysatorHCID 1140TolueneLösungsmittel

Reaktionsbedingungen

Temperatur
110 °C

Versuchsvorschrift

To a 35 ml seal tube, 1-(2-bromo-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-yl)-2,2-dimethylpropane-1-one (0.25 g, 0.000606 mole) and (5-aminopyridin-2-yl)methanol (0.09 g, 0.00728 mole) was taken in toluene (3.0 ml). The reaction mixture was purged with argon for 15 min at RT and NaOtBu (0.11 g, 0.00121 mole) was added and the reaction mixture was further purged for 30 min with argon. BINAP (0.037 g, 0.000060 mole) and Pd2(dba)3 (0.027 g, 0.000030 mole) were added and the reaction mixture was heated to 110° C. for 3 hrs. After completion of the reaction, the reaction mixture was filtered through celite bed and washed with ethyl acetate. Filtrate was collected and concentrated to afford crude product which was purified using column purification by eluting with 40-50% ethyl acetate in hexanes to yield 0.1 g of 1-(2-(6-(hydroxymethyl)pyridin-3-ylamino)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one.

Aufarbeitung

  1. customTo a 35 ml seal tube
  2. customThe reaction mixture was purged with argon for 15 min at RT
  3. customthe reaction mixture was further purged for 30 min with argon
  4. customAfter completion of the reaction
  5. filtrationthe reaction mixture was filtered through celite bed
  6. washwashed with ethyl acetate
  7. customFiltrate was collected
  8. concentrationconcentrated
  9. customto afford crude product which
  10. customwas purified
  11. customcolumn purification
  12. washby eluting with 40-50% ethyl acetate in hexanes

Quellen und Nachweise

ORD-Eintrag
ord-f68197c05a504519909fdcd813f7d587
Quelldatensatz
uspto-grants-2015_11
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US09187487B2

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