Pentane-2-sulfonyl chloride → Tert-butyl 2-(3-(1-methylbutylsulfonamido)phenoxy)ethylcarbamate

HRID 716742Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 716742
[NH2:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][CH:18]=1)[O:5][CH2:6][CH2:7][NH:8][C:9](=[O:15])[O:10][C:11]([CH3:14])([CH3:13])[CH3:12].[CH3:19][CH:20]([S:24](Cl)(=[O:26])=[O:25])[CH2:21][CH2:22][CH3:23]>CN(C1C=CN=CC=1)C.N1C=CC=CC=1>[CH3:19][CH:20]([S:24]([NH:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][CH:18]=1)[O:5][CH2:6][CH2:7][NH:8][C:9](=[O:15])[O:10][C:11]([CH3:14])([CH3:13])[CH3:12])(=[O:26])=[O:25])[CH2:21][CH2:22][CH3:23]

Komponenten

5

Edukt 2

HCID 2760314Pentane-2-sulfonyl chlorideHCID 11557882tert-butyl N-[2-(3-aminophenoxy)ethyl]carbamate

Produkt 1

HCID 59316954Tert-butyl 2-(3-(1-methylbutylsulfonamido)phenoxy)ethylcarbamate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 142844-(Dimethylamino)pyridineKatalysatorHCID 1049PyridineLösungsmittel

Versuchsvorschrift

A mixture of tert-butyl 2-(3-aminophenoxy)ethylcarbamate (3) (210 mg, 1.1 mmol), 2-pentylsulfonyl chloride (4) (0.17 ml, 1.1 mmol) and DMAP (20 mg) in pyridine (5 ml) was stirred at room temperature under argon for 15 hours. The solvent was evaporated under reduced pressure. The residue was partitioned between EtOAc and 0.5 N HCl aq. The organic layer was washed with brine, dried over Na2SO4 and concentrated under reduced pressure. Purification by flash chromatography (40 to 60% EtOAc-hexanes gradient) gave tert-butyl 2-(3-(1-methylbutylsulfonamido)phenoxy)ethylcarbamate (5) as light yellow oil. Yield (160 mg, 46%). 1H NMR (400 MHz, CDCl3) δ 7.20 (t, J=8.0 Hz, 1H), 6.75-6.82 (m, 1H), 6.73-6.75 (m, 1H), 6.64-6.67 (m, 1H), 6.37 (bs, 1H), 4.96 (bs, 1H), 3.99 (t, J=6.0 Hz, 2H), 3.51 (q, J=6.0 Hz, 2H), 3.11-3.18 (m, 1H), 1.91-2.0 (m, 1H), 1.53-1.60 (m, 2H), 1.44 (s, 9H), 1.23-1.37 (m, 4H), 0.88-0.91 (m, 3H).

Aufarbeitung

  1. customThe solvent was evaporated under reduced pressure
  2. customThe residue was partitioned between EtOAc and 0.5 N HCl aq. The organic layer
  3. washwas washed with brine
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated under reduced pressure
  6. customPurification by flash chromatography (40 to 60% EtOAc-hexanes gradient)

Quellen und Nachweise

ORD-Eintrag
ord-345dbb46db9d4533b8e7e216b550761c
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09193669B2

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