Methyl 5-chloro-6-cyano-2-(3-fluorophenyl)nicotinate → Methyl 6-(aminomethyl)-5-chloro-2-(3-fluorophenyl)nicotinate

HRID 717817Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 717817
[Cl:1][C:2]1[C:3]([C:19]#[N:20])=[N:4][C:5]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=2)=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8]>CO.[Pd]>[NH2:20][CH2:19][C:3]1[C:2]([Cl:1])=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[C:5]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=2)[N:4]=1

Komponenten

4

Edukt 1

HCID 58515932Methyl 5-chloro-6-cyano-2-(3-fluorophenyl)nicotinate

Produkt 1

HCID 58515976Methyl 6-(aminomethyl)-5-chloro-2-(3-fluorophenyl)nicotinate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

Methyl 5-chloro-6-cyano-2-(3-fluorophenyl)nicotinate (1.3 g, 4.5 mmol) was stirred in methanol (60 mL), and 5% palladium on carbon (1.0 g) was added. The mixture was degassed three times and placed under a balloon pressure of hydrogen for 4 hours. A solution of 0.5 M sodium methoxide in methanol (45 mL) was added and the mixture was filtered through celite. The filtrates were evaporated and the residue was triturated with dichloromethane. The solids were filtered and washed with dichloromethane to give the desired compound contaminated with 30% dechlorinated byproduct (1.3 g, 100%). LCMS calculated for C14H13ClFN2O2 (M+H)+: m/z=295.1. found: 295.0.

Aufarbeitung

  1. customThe mixture was degassed three times
  2. additionA solution of 0.5 M sodium methoxide in methanol (45 mL) was added
  3. filtrationthe mixture was filtered through celite
  4. customThe filtrates were evaporated
  5. customthe residue was triturated with dichloromethane
  6. filtrationThe solids were filtered
  7. washwashed with dichloromethane

Quellen und Nachweise

ORD-Eintrag
ord-a8aecba26b3d4cb3ae1d26dccdd1052b
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09193721B2

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