Cyclobutylamine → HCID 57633529, Verbindung

HRID 722148Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 722148
[S:1]([O:5][C:6]1[C:7](=[CH:9][CH:10]=[CH:11][CH:12]=1)[OH:8])([OH:4])(=[O:3])=O.[CH:13]1([NH2:17])[CH2:16][CH2:15][CH2:14]1>C(Cl)Cl.CN(C=O)C>[OH:8][C:7]1[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=1[O:5][S:1](=[O:3])(=[O:4])[NH:17][CH:13]1[CH2:16][CH2:15][CH2:14]1

Komponenten

5

Edukt 2

HCID 75645CyclobutylamineHCID 30838792-Hydroxyphenyl hydrogen sulfate

Produkt 1

HCID 57633529HCID 57633529, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Cyclobutyl-sulfamic acid 2-hydroxy-phenyl ester was prepared by adding a solution of catechol sulphate (1.32 g, 7.7 mmol) in DCM (2 ml) to a stirred solution of cyclobutylamine (600 μl, 7.0 mmol) and TEA (1.07 ml, 7.7 mmol) in DMF at 0° C., and stirring for 3 hours at this temperature. The mixture was quenched with 1M HCl (50 ml) and extracted with diethyl ether. The organic extract was washed with water, brine, dried and concentrated to dryness. Quantitative yield.

Aufarbeitung

  1. customThe mixture was quenched with 1M HCl (50 ml)
  2. extractionextracted with diethyl ether
  3. extractionThe organic extract
  4. washwas washed with water, brine
  5. customdried
  6. concentrationconcentrated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-cc413cc509c3422c8cffb0a66d4b3418
Quelldatensatz
uspto-grants-2006_11
Patentnummer
US07138400B2

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