1-(3-fluoro-4-nitrophenyl)-1H-1,2,4-triazole → 2-Fluoro-4-(1,2,4-triazol-1-yl)phenylamine

HRID 722198

Reaktionsgleichung

Reaktionsgleichung von HRID 722198
[H][H].[F:3][C:4]1[CH:5]=[C:6]([N:13]2[CH:17]=[N:16][CH:15]=[N:14]2)[CH:7]=[CH:8][C:9]=1[N+:10]([O-])=O>[Pd].O1CCCC1>[NH2:10][C:9]1[CH:8]=[CH:7][C:6]([N:13]2[CH:17]=[N:16][CH:15]=[N:14]2)=[CH:5][C:4]=1[F:3]

Komponenten

5

Edukt 2

HCID 218839191-(3-fluoro-4-nitrophenyl)-1H-1,2,4-triazoleHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 218838662-Fluoro-4-(1,2,4-triazol-1-yl)phenylamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Hydrogen was introduced under atmospheric pressure into the mixture consisting of 260 mg of 1-(3-fluoro-4-nitrophenyl)-1H-[1,2,4]triazole, 30 mg of Pd/C and 30 ml of tetrahydrofuran until the theoretical amount had been taken up. After filtering off the catalyst with suction and concentrating the mixture under reduced pressure, the remaining oily residue was purified by column chromatography (solvent: 98:2 dichloromethane:methanol; silica gel).

Aufarbeitung

  1. filtrationAfter filtering off the catalyst with suction
  2. concentrationconcentrating the mixture under reduced pressure
  3. customthe remaining oily residue was purified by column chromatography (solvent: 98:2 dichloromethane:methanol; silica gel)

Quellen und Nachweise

ORD-Eintrag
ord-762ba5ff5a6e4357a88537fe8142c26b
Quelldatensatz
uspto-grants-2006_11
Patentnummer
US07138414B2

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