N-methyl-2-pyrrolidone → 1-(4-Fluoro-2-nitrophenyl)piperidine-3-carboxamide

HRID 722232Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 722232
F[C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[NH:12]1[CH2:20][CH2:19][CH2:18][CH:14]([C:15]([NH2:17])=[O:16])[CH2:13]1.CN1C(=O)CCC1>O>[F:8][C:5]1[CH:6]=[CH:7][C:2]([N:12]2[CH2:20][CH2:19][CH2:18][CH:14]([C:15]([NH2:17])=[O:16])[CH2:13]2)=[C:3]([N+:9]([O-:11])=[O:10])[CH:4]=1

Komponenten

5

Edukt 3

HCID 13387N-methyl-2-pyrrolidoneHCID 677672,5-DifluoronitrobenzeneHCID 929803-Piperidinecarboxamide

Produkt 1

HCID 218839121-(4-Fluoro-2-nitrophenyl)piperidine-3-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

The mixture consisting of 1.62 g of 2,5-difluoronitrobenzene, 1.9 g of nipecotamide and 10 ml of NMP was heated with stirring to 80° C. for 2 hours. After the mixture had been allowed to cool, 30 ml of water were added and the mixture was stirred at RT for 30 minutes. The precipitated solid was filtered off with suction and dried under reduced pressure.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureto cool
  3. stirringthe mixture was stirred at RT for 30 minutes
  4. filtrationThe precipitated solid was filtered off with suction
  5. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-74461f99bffd49d08ace61153edfed1a
Quelldatensatz
uspto-grants-2006_11
Patentnummer
US07138414B2

Notizen zur Reaktion

Wird geladen…