Methyl propionate → 3-(4-Benzyloxy-phenyl)-isothiazol-5-carboxylic acid methyl ester

HRID 72316

Reaktionsgleichung

Reaktionsgleichung von HRID 72316
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2OC(=O)[S:17][N:16]=2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:21]([O:25][CH3:26])(=[O:24])[CH2:22][CH3:23]>ClC1C=CC=CC=1>[CH3:26][O:25][C:21]([C:22]1[S:17][N:16]=[C:15]([C:12]2[CH:11]=[CH:10][C:9]([O:8][CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[CH:14][CH:13]=2)[CH:23]=1)=[O:24]

Komponenten

4

Edukt 2

HCID 11124Methyl propionateHCID 595495255-(4-Benzyloxyphenyl)-[1,3,4]oxathiazol-2-one

Produkt 1

HCID 666177513-(4-Benzyloxy-phenyl)-isothiazol-5-carboxylic acid methyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7964ChlorobenzeneLösungsmittel

Versuchsvorschrift

5-(4-benzyloxy-phenyl)-[1,3,4]oxathiazol-2-one (0.4 g, 1.4 mmol) and 0.23 ml of methyl propionate were dissolved in 10 ml of chlorobenzene and then refluxed overnight. The solvent was distilled off under reduced pressure and the obtained crude compound was purified by silica gel column chromatography to obtain 3-(4-benzyloxy-phenyl)-isothiazol-5-carboxylic acid methyl ester as a desired compound.

Aufarbeitung

  1. temperaturerefluxed overnight
  2. distillationThe solvent was distilled off under reduced pressure
  3. customthe obtained crude compound
  4. customwas purified by silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-bae299a0dd6140dd87b26a0cdc892800
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08828992B2

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