Chlorosuccinimide → Methyl 6-amino-5-bromo-3-chloropyridine-2-carboxylate

HRID 723525Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 723525
[NH2:1][C:2]1[N:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:5]=[CH:4][C:3]=1[Br:12].[Cl:13]N1C(=O)CCC1=O>C(O)(=O)C>[NH2:1][C:2]1[N:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[C:5]([Cl:13])=[CH:4][C:3]=1[Br:12]

Komponenten

4

Edukt 2

HCID 31398ChlorosuccinimideHCID 10704661Methyl 6-amino-5-bromopicolinate

Produkt 1

HCID 21873807Methyl 6-amino-5-bromo-3-chloropyridine-2-carboxylateAusbeute 95,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

To a solution methyl 6-amino-5-bromopyridine-2-carboxylate (20.04 g) in acetic acid (900 ml) was added N-chlorosuccinimide (13.96 g) and the resultant solution was heated to 120° C. for 1 hour. The solution was then evaporated and treated with excess aqueous sodium bicarbonate and extracted with dichloromethane. The organic fraction was dried and evaporated to give the product (21.98 g).

Aufarbeitung

  1. customThe solution was then evaporated
  2. additiontreated with excess aqueous sodium bicarbonate
  3. extractionextracted with dichloromethane
  4. customThe organic fraction was dried
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-5939f59c7bb94a1cb073784e484478f9
Quelldatensatz
uspto-grants-2006_11
Patentnummer
US07141564B2

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