Hydrogen Peroxide → Pyridine, 3-methoxy-, 1-oxide

Temperatur

70 °C

3-Methoxypyridine (20.08g, 209 mmol) was dissolved in 100 mL of acetic acid. 30% H2O2 (28.3 mL, 275 mmol) was added and the reaction mixture was heated at 70° C. for six h. The cooled reaction mixture was concentrated and the residue dissolved in CH2Cl2 and stirred overnight with 20 g of solid potassium carbonate. The mixture was filtered and concentrated to give compound 762A (25.2g, 100%) as a light yellow solid which was characterized by 1H NMR and carried on to the next step.

1. customThe cooled reaction mixture
2. concentrationwas concentrated
3. dissolutionthe residue dissolved in CH2Cl2
4. filtrationThe mixture was filtered
5. concentrationconcentrated

ORD-Eintrag

ord-4810d2db956f4b21951da1528e907e51

Quelldatensatz

uspto-grants-2006_11

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07141578B2