Hydrogen Peroxide → Pyridine, 2-methoxy-, 1-oxide

Temperatur

80 °C

This compound, originally prepared by H. J. Den Hertog and M. Van Ammers, Rec. Trav. Chim. 1955, 74, 1160, was synthesized using a different procedure. To a solution of 21.83 of 2-methoxypyridine (0.2 mol) in glacial acetic acid (80 ml), was cautiously added 30% hydrogen peroxide (20 ml). The stirred mixture was heated to 80° C. for 3 hrs, and cooled to room temperature. An additional 20 ml of 30% H2O2 was added, and the clear solution was heated at 80° C. for 12 hrs. The solution was concentrated to half the original volume under vacuum, and 100 ml of water was added. The solution was reconcentrated, and the process was repeated two times (2×100 ml H2O). The syrup was placed under vacuum to remove remaining water and acetic acid. After time, a white solid formed. The material obtained in quantitative yield was used without further purification; M.P. 128°-130° C.; IR (KBr) 3447, 1613, 1570, 1508 1447, 1316, 1214, 1015, 764 cm-1 ; 1H NMR (CDCl3) δ 4.05 (s, 3H), 6.91 (d, 1H, J=8.0 Hz), 6.92 (m, 1H), 7.33 (dt, 2H, J=8.0, 1.6 Hz), 8.3 (dd, 1H, J=6.3, 1.6 Hz). HRMS Calcd. for C6H7NO2 : 125.0477. Found: 125.0474.

1. customThis compound, originally prepared by H
2. custom1955, 74, 1160, was synthesized
3. temperaturecooled to room temperature
4. temperaturethe clear solution was heated at 80° C. for 12 hrs
5. concentrationThe solution was concentrated to half the original volume under vacuum, and 100 ml of water
6. additionwas added
7. customto remove
8. customAfter time, a white solid formed
9. customThe material obtained in quantitative yield
10. customwas used without further purification

ORD-Eintrag

ord-f08c1837a0a4446c8b09fe4c7d392036

Quelldatensatz

uspto-grants-1998_01

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05707992