3-Quinolinecarboxylic acid, 4-chloro-8-methoxy-, ethyl ester → Ethyl 8-methoxy-4-(4-methoxy-3-thienylamino)quinoline-3-carboxylate

Beteiligte Stoffe

Reaktionsschritte

Ethyl 8-methoxy-4-chloroquinoline-3-carboxylate (1.5 g, 0.0056 mol) and 4-methoxy-3-aminothiophene (1.46 g, 0.0112 mol) in 1,4 dioxan (20 ml) were heated under reflux for 4 hours. The solid which had formed was collected by filtration and dried. The solid was dissolved in chloroform, washed with sodium carbonate solution (50 ml), then water, dried over magnesium sulphate, filtered and evaporated under reduced pressure to give a yellow solid.

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