Triethylamine → N-[2-[bis(Phenylmethyl)amino]ethyl]-propanamide

HRID 728814

Reaktionsgleichung

Reaktionsgleichung von HRID 728814
[CH2:1]([N:8]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:9][CH2:10][NH2:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.[C:26](Cl)(=[O:29])[CH2:27][CH3:28]>C1COCC1>[C:13]1([CH2:12][N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:9][CH2:10][NH:11][C:26](=[O:29])[CH2:27][CH3:28])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 62324Propionyl chlorideHCID 6394114N1,N1-Dibenzylethane-1,2-diamine

Produkt 1

HCID 54327882N-[2-[bis(Phenylmethyl)amino]ethyl]-propanamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

To a chilled solution of 5.0 g (21 mmol) N,N-dibenzylethylenediamine and 30mL (21 mmol) triethylamine in 20 mL THF is added 1.8 mL (21 mmol) propionylchloride, dropwise. The temperature of the reaction mixture is maintained below 0° C. during addition. The reaction mixture is stirred for 30minutes at 0° C. After this time, the reaction mixture is filtered and the solvents are evaporated to give the product which can be purified via column chromatography.

Aufarbeitung

  1. temperatureThe temperature of the reaction mixture is maintained below 0° C. during addition
  2. filtrationAfter this time, the reaction mixture is filtered
  3. customthe solvents are evaporated
  4. customto give the product which
  5. customcan be purified via column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-6c796ddafef5454ba34e40ccd9db3930
Quelldatensatz
uspto-grants-1991_09
Patentnummer
US05051423

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