Benzo(F)Quinoline → Mls002703342

HRID 729204

Reaktionsgleichung

Reaktionsgleichung von HRID 729204
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.C(Cl)Cl.[CH:14]1[C:23]2[C:22]3[CH:24]=[CH:25][CH:26]=[CH:27][C:21]=3[CH:20]=[CH:19][C:18]=2[N:17]=[CH:16][CH:15]=1.[C-:28]#[N:29].[K+]>C(Cl)Cl.O>[C:28]([CH:16]1[CH:15]=[CH:14][C:23]2[C:22]3[CH:24]=[CH:25][CH:26]=[CH:27][C:21]=3[CH:20]=[CH:19][C:18]=2[N:17]1[C:1](=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)#[N:29]

Komponenten

7

Edukt 4

HCID 6796Benzo(F)QuinolineHCID 7412Benzoyl chlorideHCID 9032Potassium CyanideHCID 21908982Water methylene chloride

Produkt 1

HCID 262649Mls002703342

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

648 μl (5.58 mmol) benzoyl chloride was added to a two phase system of water/methylene chloride over a period of two hours. These two layers contain 500 mg (2.79 mmol) of benzo(f)chinolin in the methylene chloride layer and 545 mg (8.37 mmol) KCN in water. Stirring was continued for 6 hours. The organic phase was separated and washed with water, 5% hydrochloric acid, water, 5% NaOH solution, and again with water. After drying over magnesium sulfate, the solution was evaporated to dryness.

Aufarbeitung

  1. customThe organic phase was separated
  2. washwashed with water, 5% hydrochloric acid, water, 5% NaOH solution
  3. dry with materialAfter drying over magnesium sulfate
  4. customthe solution was evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-7edc6e62b38842c4962ead419202b6d3
Quelldatensatz
uspto-grants-2009_09
Patentnummer
US07582295B2

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