1-Methyl-4-piperidone → HCID 1476965, Verbindung

HRID 729639Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 729639
[CH3:1][N:2]1[CH2:7][CH2:6][C:5](=[O:8])[CH2:4][CH2:3]1.CO[CH:11](OC)[N:12]([CH3:14])[CH3:13]>C1(C)C=CC=CC=1>[CH3:11][N:12]([CH:14]=[C:4]1[C:5](=[O:8])[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3]1)[CH3:13]

Komponenten

4

Edukt 2

HCID 740491-Methyl-4-piperidoneHCID 78373Dimethylformamide dimethyl acetal

Produkt 1

HCID 1476965HCID 1476965, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

To a solution of 1-methylpiperidin-4-one (10 g, 88 mmol) in toluene (100 mL) was added 1,1-dimethoxy-N,N-dimethylmethanamine (52.7 g, 0.442 mol). The solution was heated to reflux overnight. The solvents were evaporated in vacuo, heptane (100 ml) was added and the solvents evaporated again to give the desired product. NMR indicated that the product was 70-80% pure and it was used in the next step without further purification.

Aufarbeitung

  1. temperatureThe solution was heated
  2. temperatureto reflux overnight
  3. customThe solvents were evaporated in vacuo, heptane (100 ml)
  4. additionwas added
  5. customthe solvents evaporated again

Quellen und Nachweise

ORD-Eintrag
ord-1878070c0c26483a8a9bc4ce5011bea2
Quelldatensatz
uspto-grants-2009_09
Patentnummer
US07582643B2

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