Water → 5-Amino-1-((4-fluorophenyl)(phenyl)methyl)-1H-pyrrole-3-carbonitrile

HRID 730424Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 730424
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:15][CH:16]=[C:17]([CH2:20][C:21]#[N:22])[C:18]#[N:19])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:4][CH:3]=1.[O-]CC.[K+].O>O1CCCC1.C(O)C>[NH2:22][C:21]1[N:15]([CH:8]([C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:16]=[C:17]([C:18]#[N:19])[CH:20]=1

Komponenten

6

Edukt 3

HCID 962WaterHCID 23670592Potassium ethoxideHCID 690558642-({[(4-Fluorophenyl)(phenyl)methyl]amino}methylidene)butanedinitrile

Produkt 1

HCID 690583295-Amino-1-((4-fluorophenyl)(phenyl)methyl)-1H-pyrrole-3-carbonitrile

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 2-({[(4-fluorophenyl)(phenyl)methyl]amino}methylene)butanedinitrile (13.9 g, 47.7 mmol) in tetrahydrofuran (50 ml) and ethanol (50 ml) was slowly added potassium ethoxide (7.05 g, 83.8 mmol), the mixture was stirred at room temperature for 1 hour and poured into iced water. The product was extracted with ethyl acetate, the extract was washed with water, dried over anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure to give the objective product as oily matter.

Aufarbeitung

  1. extractionThe product was extracted with ethyl acetate
  2. washthe extract was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. distillationthe solvent was distilled off under reduced pressure
  5. customto give the objective product as oily matter

Quellen und Nachweise

ORD-Eintrag
ord-3fa949b04f154c71aa98cf877af98d0e
Quelldatensatz
uspto-grants-2009_09
Patentnummer
US07582651B2

Notizen zur Reaktion

Wird geladen…