Reaktionsgleichung
[C:1]([C:5]1[CH:6]=[CH:7][C:8]2[N:12]=[C:11](Cl)[NH:10][C:9]=2[CH:14]=1)([CH3:4])([CH3:3])[CH3:2].Cl.[Cl:16][C:17]1[C:18]([N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)=NC=C[CH:22]=1.[CH:29]([N:32](CC)C(C)C)(C)[CH3:30]>>[C:1]([C:5]1[CH:6]=[CH:7][C:8]2[N:12]=[C:11]([N:26]3[CH2:25][CH2:24][N:23]([C:18]4[CH:30]=[CH:29][N:32]=[CH:22][C:17]=4[Cl:16])[CH2:28][CH2:27]3)[NH:10][C:9]=2[CH:14]=1)([CH3:4])([CH3:3])[CH3:2]Komponenten
4
Versuchsvorschrift
The benzoimidazole from step (b) above (0.209 g, 1 mmol), 1-(3-chloropyridin-2-yl)piperazine hydrochloride (0.304 g, 1.3 mmol, Example 3b) and N,N-diisopropylethylamine (0.45 mL, 2.6 mmol, Aldrich) were reacted under the conditions of Example 1d to give the title compound as a yellow amorphous solid. MS (ESI, pos. ion) m/z: 371 (M+1).
Quellen und Nachweise
- ORD-Eintrag
- ord-dc9cb52a50f34f1eb8adb98af13b33b5
- Quelldatensatz
- uspto-grants-2009_09
- Patentnummer
- US07582761B2
Verknüpfte Notizen
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