Piperazine → (5-Chloro-6-(piperazin-1-yl)pyridin-3-yl)methanol

Reaktionsgleichung

[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][OH:10])[CH:5]=[N:6][C:7]=1Cl.[NH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1.C(N(CC)C(C)C)(C)C>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][OH:10])[CH:5]=[N:6][C:7]=1[N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1

Komponenten

Edukt 3

HCID 4837Piperazine

HCID 81531Diisopropylethylamine

HCID 21882961(5,6-Dichloropyridin-3-yl)methanol

Produkt 1

HCID 11514124(5-Chloro-6-(piperazin-1-yl)pyridin-3-yl)methanol

Versuchsvorschrift

A mixture of 5,6-dichloro-3-pyridinemethanol (0.71 g, 4 mmol, TCI-US), piperazine (0.52 g, 6 mmol) and N,N-diisopropylethylamine (1 mL, 5.8 mmol, Aldrich) was reacted under the conditions of Example 43a to give the title compound as a light-yellow solid. MS (ESI, pos. ion) m/z: 228 (M+1).