Hydrazine hydrate (1:1) → 3-Cyanobenzohydrazide

HRID 732027

Reaktionsgleichung

Reaktionsgleichung von HRID 732027
C[O:2][C:3](=O)[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]#[N:11])[CH:5]=1.O.[NH2:14][NH2:15]>C(O)C>[C:10]([C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=1)[C:3]([NH:14][NH2:15])=[O:2])#[N:11]

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 83554Benzoic acid, 3-cyano-, methyl ester

Produkt 1

HCID 219426583-CyanobenzohydrazideAusbeute 52,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 3-cyano-benzoic acid methyl ester (2 g, 12 mmol) and hydrazine monohydrate (0.60 mL, 12 mmol) in ethanol (10 mL) was stirred at room temperature overnight. The reaction mixture was concentrated and then the residue was triturated with diethyl ether to afford 3-cyano-benzoic acid hydrazide (1.02 g, 51%, pink solid). 1H NMR (DMSO) □ (ppm): 10.31 (s, 1H), 8.21 (m, 1H), 8.11 (m, 1H), 7.99 (m, 1H), 7.70 (m, 1H), 4.50 (s, 1H).

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was triturated with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-9de038fd9408409d98c15b6450e01aa9
Quelldatensatz
uspto-grants-2009_09
Patentnummer
US07585881B2

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