Morpholine → HCID 86760960, Verbindung
Reaktionsgleichung
C(OC([N:8]1[C:12]2=[C:13]([Cl:26])[N:14]=[CH:15][C:16]([C:17](=[O:25])[NH:18][CH:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)=[C:11]2[C:10]([CH3:27])=[CH:9]1)=O)(C)(C)C.[NH:28]1[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1>CO>[ClH:26].[O:22]1[CH2:21][CH2:20][CH:19]([NH:18][C:17]([C:16]2[C:11]3[C:10]([CH3:27])=[CH:9][NH:8][C:12]=3[C:13]([N:28]3[CH2:33][CH2:32][O:31][CH2:30][CH2:29]3)=[N:14][CH:15]=2)=[O:25])[CH2:24][CH2:23]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Prepared in a similar manner to Example 11 (c) from 7-chloro-3-methyl-4-(tetrahydro-pyran-4-ylcarbamoyl)-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester and morpholine (71 mg) except that the hydrochloride salt was formed using methanol instead of dichloromethane as solvent to give the title compound (40 mg).