Water → 1-(2-Bromo-3,5,6-trimethylphenyl)ethanone

To a mixture of 1-bromo-2,4,5-trimethylbenzene (5.0 g, 25.0 mmol) and acetyl chloride (2.45 ml, 34.5 mmol) in dichloromethane (50 ml) was added aluminium chloride (4.42 g, 33.1 mmol) in dichloromethane (50 ml) and the reaction mixture was stirred at room temperature for 18 h. The mixture was poured into water and the two layers were separated. The organic phase was washed with saturated aqueous sodium hydrogen carbonate solution, dried (MgSO4) and filtered through silica. The filtrate was concentrated in vacuo to give the title compound (5.50 g).

1. customthe two layers were separated
2. washThe organic phase was washed with saturated aqueous sodium hydrogen carbonate solution
3. dry with materialdried (MgSO4)
4. filtrationfiltered through silica
5. concentrationThe filtrate was concentrated in vacuo

ORD-Eintrag

ord-de994c566245469aa291f3d09cf5d79b

Quelldatensatz

uspto-grants-2009_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07592362B2