Morpholine → 5-(Cyclopropylmethyl-sulfamoyl)-2-morpholin-4-yl-benzoic acid

HRID 736158

Reaktionsgleichung

Reaktionsgleichung von HRID 736158
CS(C1C=CC(N2CCCC2)=C(C=1)C(O)=O)(=O)=O.Cl[C:20]1[CH:28]=[CH:27][C:26]([S:29](=[O:36])(=[O:35])[NH:30][CH2:31][CH:32]2[CH2:34][CH2:33]2)=[CH:25][C:21]=1[C:22]([OH:24])=[O:23].[NH:37]1[CH2:42][CH2:41][O:40][CH2:39][CH2:38]1>>[CH:32]1([CH2:31][NH:30][S:29]([C:26]2[CH:27]=[CH:28][C:20]([N:37]3[CH2:42][CH2:41][O:40][CH2:39][CH2:38]3)=[C:21]([CH:25]=2)[C:22]([OH:24])=[O:23])(=[O:36])=[O:35])[CH2:34][CH2:33]1

Komponenten

4

Edukt 3

HCID 8083MorpholineHCID 290355802-Chloro-5-(cyclopropylmethyl-sulfamoyl)-benzoic acidHCID 597934895-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid

Produkt 1

HCID 597935855-(Cyclopropylmethyl-sulfamoyl)-2-morpholin-4-yl-benzoic acidAusbeute 33 %

Versuchsvorschrift

The title compound was synthesised according to the procedure described for the synthesis of 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid from 2-Chloro-5-(cyclopropylmethyl-sulfamoyl)-benzoic acid and morpholine and obtained in 33% yield.

Aufarbeitung

  1. customobtained in 33% yield

Quellen und Nachweise

ORD-Eintrag
ord-93b4bc65ac98426db179c5aa2a7c0059
Quelldatensatz
uspto-grants-2009_09
Patentnummer
US07595314B2

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