1-Phenylpiperazine → (2-Fluoro-5-nitro-phenyl)(4-phenyl-piperazin-1-yl)-methanone

Reaktionsgleichung

[F:1][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[C:4](Cl)=[O:5].[C:14]1([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[F:1][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[C:4]([N:23]1[CH2:24][CH2:25][N:20]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:21][CH2:22]1)=[O:5]

Komponenten

Edukt 2

HCID 70961-Phenylpiperazine

HCID 109765702-Fluoro-5-nitrobenzoyl chloride

Produkt 1

HCID 59793731(2-Fluoro-5-nitro-phenyl)(4-phenyl-piperazin-1-yl)-methanone

Versuchsvorschrift

The title compound was prepared according to the procedure described for example 46 from 2-Fluoro-5-nitro-benzoyl chloride and 1-phenyl-piperazine (70%, orange solid, MS (m/e): 330.1 (M+H, 100%)

Quellen und Nachweise

ORD-Eintrag: ord-c6f9222e8906459a93a9399cd07f4bfa
Quelldatensatz: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07595314B2

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