6-Bromo-N-methoxy-N-methylpicolinamide → (6-Bromo-pyridin-2-yl)-(4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanone

HRID 736341

Reaktionsgleichung

Reaktionsgleichung von HRID 736341
Br[C:2]1[C:10]2[C:9]([Cl:11])=[N:8][CH:7]=[N:6][C:5]=2[N:4]([CH:12]([CH3:14])[CH3:13])[CH:3]=1.CON(C)[C:18]([C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([Br:26])[N:21]=1)=[O:19].BrC1C=C(C(C2C3C(Cl)=NC=NC=3N(C(C)C)C=2)=O)C=NC=1>>[Br:26][C:22]1[N:21]=[C:20]([C:18]([C:2]2[C:10]3[C:9]([Cl:11])=[N:8][CH:7]=[N:6][C:5]=3[N:4]([CH:12]([CH3:14])[CH3:13])[CH:3]=2)=[O:19])[CH:25]=[CH:24][CH:23]=1

Komponenten

4

Edukt 3

HCID 247303326-Bromo-N-methoxy-N-methylpicolinamideHCID 457894285-Bromo-4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidineHCID 86603152(5-Bromo-pyridin-3-yl)-(4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanone

Produkt 1

HCID 86603155(6-Bromo-pyridin-2-yl)-(4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanoneAusbeute 69 %

Versuchsvorschrift

The title compound (34.0 g, 69%) was prepared from 5-Bromo-4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine (35.8 g, 130.5 mmol) and 6-Bromo-pyridine-2-carboxylic acid methoxy-methyl-amide (32.0 g, 130.5 mmol) by procedures analogous to those described for the preparation (5-Bromo-pyridin-3-yl)-(4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanone. MS: 380.6 (MH+); HPLC Rf: 6.05 min. (HPLC method 4); HPLC purity: 100%.

Quellen und Nachweise

ORD-Eintrag
ord-8eda0b4f3ae143f884c7a41f07949abb
Quelldatensatz
uspto-grants-2009_09
Patentnummer
US07595325B2

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