Sodium Bicarbonate → HCID 178497918, Verbindung

HRID 736482Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 736482
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][NH:8]2)=[C:4](Cl)[N:3]=1.Cl.[CH3:13][O:14][C:15](=[O:24])[C:16]1[CH:21]=[CH:20][C:19]([CH2:22][NH2:23])=[CH:18][CH:17]=1.C([O-])(O)=O.[Na+]>O>[CH3:13][O:14][C:15](=[O:24])[C:16]1[CH:21]=[CH:20][C:19]([CH2:22][NH:23][C:4]2[N:3]=[C:2]([Cl:1])[N:10]=[C:9]3[C:5]=2[N:6]=[CH:7][NH:8]3)=[CH:18][CH:17]=1

Komponenten

5

Edukt 3

HCID 516892Sodium BicarbonateHCID 2729253Methyl 4-(aminomethyl)benzoate hydrochlorideHCID 1784188752,6-dichloro-1H-purine

Produkt 1

HCID 178497918HCID 178497918, VerbindungAusbeute 60 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A suspension of 2,6-dichloro-9H-purine (1 g, 5.29 mmol), 4-aminomethyl-benzoic acid methyl ester hydrochloride (1.2 equiv., 1.28 g) and NaHCO3 (2.1 equiv., 935 mg) in water was heated at 100° C. The homogeneous solution thus formed was refluxed 30 min. The resulting white precipitate was filtered, washed with cold water and dried under vacuum giving the title compound 241 (1 g, 3.14 mmol, 60%). LRMS calc:317.7, found: 318.3 (MH)+.

Aufarbeitung

  1. customThe homogeneous solution thus formed
  2. temperaturewas refluxed 30 min
  3. filtrationThe resulting white precipitate was filtered
  4. washwashed with cold water
  5. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-e54780fe73f34ea39a9af4291ec90730
Quelldatensatz
uspto-grants-2009_09
Patentnummer
US07595343B2

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