1,2-Benzisothiazol-3(2H)-one → 3-Oxo-3H-benzo[d]isothiazole-2-carboxylic acid dodecylamide

HRID 736621

Reaktionsgleichung

Reaktionsgleichung von HRID 736621
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3](=[O:10])[NH:2]1.[CH2:11]([N:23]=[C:24]=[O:25])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]>>[CH2:11]([NH:23][C:24]([N:2]1[C:3](=[O:10])[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[S:1]1)=[O:25])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]

Komponenten

3

Edukt 2

HCID 175201,2-Benzisothiazol-3(2H)-oneHCID 77873Dodecane, 1-isocyanato-

Produkt 1

HCID 111526833-Oxo-3H-benzo[d]isothiazole-2-carboxylic acid dodecylamide

Versuchsvorschrift

Following the synthetic procedure of 6a as described in Example 1, compound 6g (78% yield) was synthesized from benzo[d]isothiazol-3-one and dodecyl isocyanate as a white solid. mp 66-67° C.; IR(CHCl3) 3279, 1709, 1660, 1536 cm−1; 1H-NMR (CDCl3) δ0.87 (t, J=6.8 Hz, 3H), 1.20-1.39 (m, 18H), 1.59-1.66 (m, 2H), 3.40-3.46 (m, 2H), 7.42 (t, J=7.6 Hz, 1H), 7.57 (d, J=7.6 Hz, 1H), 7.69 (t, J=7.6 Hz, 1H), 8.01 (d, J=7.6 Hz, 1H), 8.87 (br s, 1H); ESIMS m/e 363 (M++1).

Quellen und Nachweise

ORD-Eintrag
ord-368d47d57ae34a7f80ebb158ddfc472b
Quelldatensatz
uspto-grants-2009_09
Patentnummer
US07595403B2

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