Potassium Carbonate → (S)-2-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-1-[4-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-piperazin-1-yl]-4-[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-yl]-butan-1,4-dione

Reaktionsgleichung

[CH3:1][N:2]1[CH:7]2[CH2:8][CH2:9][CH:3]1[CH2:4][CH:5]([N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1)[CH2:6]2.[NH2:16][C:17]1[C:48]([C:49]([F:52])([F:51])[F:50])=[CH:47][C:20]([CH2:21][C@@H:22]([CH2:26][C:27](=[O:46])[N:28]2[CH2:33][CH2:32][CH:31]([N:34]3[CH2:40][CH2:39][C:38]4[CH:41]=[CH:42][CH:43]=[CH:44][C:37]=4[NH:36][C:35]3=[O:45])[CH2:30][CH2:29]2)[C:23](O)=[O:24])=[CH:19][C:18]=1[Cl:53].CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.C(N(C(C)C)C(C)C)C.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[NH2:16][C:17]1[C:48]([C:49]([F:51])([F:50])[F:52])=[CH:47][C:20]([CH2:21][C@@H:22]([CH2:26][C:27]([N:28]2[CH2:33][CH2:32][CH:31]([N:34]3[CH2:40][CH2:39][C:38]4[CH:41]=[CH:42][CH:43]=[CH:44][C:37]=4[NH:36][C:35]3=[O:45])[CH2:30][CH2:29]2)=[O:46])[C:23]([N:13]2[CH2:14][CH2:15][N:10]([CH:5]3[CH2:6][CH:7]4[N:2]([CH3:1])[CH:3]([CH2:9][CH2:8]4)[CH2:4]3)[CH2:11][CH2:12]2)=[O:24])=[CH:19][C:18]=1[Cl:53]