Leucine, N-carboxy-, N-benzyl ester, L- → N-[N-[(Phenylmethoxy)carbonyl]-L-leucyl]-L-norleucinol
Reaktionsgleichung
[C:1]1([CH2:7][O:8][C:9]([NH:11][C@H:12]([C:17]([OH:19])=O)[CH2:13][CH:14]([CH3:16])[CH3:15])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:20][C@H:21]([CH2:26][OH:27])[CH2:22][CH2:23][CH2:24][CH3:25]>>[C:1]1([CH2:7][O:8][C:9]([NH:11][C@H:12]([C:17]([NH:20][C@H:21]([CH2:26][OH:27])[CH2:22][CH2:23][CH2:24][CH3:25])=[O:19])[CH2:13][CH:14]([CH3:15])[CH3:16])=[O:10])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1Komponenten
3
Versuchsvorschrift
N-[(phenylmethoxy)carbonyl]-L-leucine was used instead of 1-[[(phenylmethoxy)carbonyl]amino]cyclohexanecarboxylic acid, and L-norleucinol was used instead of L-valinol in the process according to Reference Example 178 to obtain 421 mg (58%) of the title compound.
Quellen und Nachweise
- ORD-Eintrag
- ord-ac37e11a459a4ff08d4c2ee4c1c96d22
- Quelldatensatz
- uspto-grants-2014_09