Pamidronic Acid → Alendronic Acid

HRID 74141

Reaktionsgleichung

Reaktionsgleichung von HRID 74141
[CH2:1]([C:4]([P:10]([OH:13])([OH:12])=[O:11])([P:6]([OH:9])([OH:8])=[O:7])[OH:5])[CH2:2]N.C[CH2:15][N:16](CC)CC>O>[CH2:2]([CH2:15][NH2:16])[CH2:1][C:4]([P:10]([OH:13])([OH:12])=[O:11])([P:6]([OH:9])([OH:8])=[O:7])[OH:5]

Komponenten

4

Edukt 2

HCID 4674Pamidronic AcidHCID 8471Triethylamine

Produkt 1

HCID 2088Alendronic Acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

The NHS ester (0.35 g, 0.62 mmol) was dissolved in H2O (30 mL), and pamidronate (0.52 g, 2.23 mmol) and Et3N (1.7 mL, 12.4 mmol) were added. The reaction solution was stirred for 24 h at room temperature. Subsequently, the H2O was removed in the vacuum. The product obtained was purified by means of HPLC.

Aufarbeitung

  1. customSubsequently, the H2O was removed in the vacuum
  2. customThe product obtained
  3. customwas purified by means of HPLC

Quellen und Nachweise

ORD-Eintrag
ord-63709912d71b4b3b8f382421cafd90e3
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08829233B2

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