Decyl chloroformate → Phthalimide hydrochloride

HRID 744291

Reaktionsgleichung

Reaktionsgleichung von HRID 744291
[Cl:1]C(OCCCCCCCCCC)=O.FC1C=C2C(C(N3CCN(CC[N:33]4[C:37](=[O:38])[C:36]5=[CH:39][CH:40]=[CH:41][CH:42]=[C:35]5[C:34]4=[O:43])CC3)=NN2)=CC=1>CCOCC>[ClH:1].[C:37]1(=[O:38])[NH:33][C:34](=[O:43])[C:35]2=[CH:42][CH:41]=[CH:40][CH:39]=[C:36]12

Komponenten

4

Edukt 2

HCID 108727Decyl chloroformateHCID 18467209N-[2-[4-(6-fluoro1H-indazol-3-yl)-1-piperazinyl]ethyl]phthalimide

Produkt 1

HCID 22266261Phthalimide hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

A mixture of decanyl chloroformate (2.4 g, 11 mmol), and N-[2-[4-(6-fluoro-1H-indazol-3-yl)-1-piperazinyl]ethyl]phthalimide (3.9 g, 10 mmol) was warmed on the steam bath for 15 minutes. The reaction was allowed to cool to ambient temperature, and then ether was added to the residue. The resulting solid was filtered to afford N-2-[4-(1-decanoxy-6-fluoro-1H-indazol-3-yl)-1-piperazinyl]ethyl]phthalimide hydrochloride.

Aufarbeitung

  1. temperaturewas warmed on the steam bath for 15 minutes
  2. filtrationThe resulting solid was filtered

Quellen und Nachweise

ORD-Eintrag
ord-24db54fe01e44a0084cc66b0e1405926
Quelldatensatz
uspto-grants-1996_09
Patentnummer
US05559116

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